TheFarm@lemmy.worldtoTenForward: Where Every Vulcan Knows Your Name@lemmy.world•I miss the days when THC didn't make me feel paranoid
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8 days agoThere is work from the same group of researchers showing that CBD + THC actually exacerbates the effects of THC on psychosis symptoms in people with schizophrenia: https://pubmed.ncbi.nlm.nih.gov/40702165/
Plus I wouldn’t be surprised if some of the beneficial effects of a gram of CBD on psychosis symptoms has to do with pharmacokinetic effects (CBD inhibits enzymes that metabolize a lot of drugs, meaning a gram of CBD in someone with Schizophrenia that is taking other medicines would increase their blood levels of the other medicines).
Not to say playing around with some CBD is a bad idea if it works for you, but the actual hard evidence on CBD acting as a counter weight to THC’s effects is pretty scant.
I brought up schizophrenia as your initial cited study mentioned the antipsychotic effect of CBD in people with schizophrenia, where you claimed that CBD is an antipsychotic.
The meta-analysis you’ve cited says that CBD does not consistently moderate the effects of THC across all outcomes and finished with a pretty lukewarm conclusion, that “CBD may interact with some acute effects of THC”.
Here’s another meta-analysis that also finds no consistent evidence that CBD improves the acute symptoms of THC: https://www.thelancet.com/journals/lanpsy/article/PIIS2215-0366(20)30074-2/fulltext
My point being - the cannabis research field is not in a place to make any kind of concrete claims about CBD reducing the effects of THC. If it were, you’d see strong conclusions coming from meta-analyses, and cannabis companies wouldn’t stop citing the research when promoting their balanced CBD-THC strains.
I don’t think it’s healthy to give people the advice that there is concrete evidence that CBD will make THC more enjoyable for them. There is no magic bullet that will make THC enjoyable for some people - although again, more power to you if it works for you.