K2 (spice, etc) is the synthetic cannabinoids (https://m.psychonautwiki.org/wiki/Synthetic_cannabinoid), which are often fairly dangerous, but are unrelated to kratom.
Kratom (https://en.wikipedia.org/wiki/Mitragyna_speciosa) is a plant that produces two substances (mitragynine, 7-hydroxymitragynine aka 7-OH) that act like opioids. The pharmacology is relatively unusual, relative to most opioids, as the primary active substances in kratom also bind to serotonin and norepinephrine receptors; other alkaloids in the plant also act as ex. NMDA antagonists which may cause a dissociative experience (vaguely along the likes of ketamine, etc).
If you don’t mind me asking, what disease? I’ve found myself in a very similar position.