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Cake day: October 26th, 2025

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  • I’ve had similar experiences with smoking, believe it or not, on a few things…

    • psilocybin
    • 5-mapb
    • 4-meo-mipt
    • amphetamine
    • methamphetamine

    Note that I am in no way advising to use any of these for any reason. This is just my anecdotal experience. In my younger years, I was a pretty liberal psychonaut. I would try things to understand it’s mental effects from the first person, never a consistent user and I’ve since left the scene.

    Anyway, smoking nicotine for over a decade, after a big enough trip I would have an afterglow that would leave me without nicotine cravings. No cravings at all for up to a week, sometimes.

    I always assumed it might be possible to have an afterglow help me get over the worst of the nicotine physical withdrawal (i.e., the first week) while powering through the rest myself — until I’d officially “quit” smoking. Never did this, though. I still vape nicotine daily.




  • The catch is that “can eat plastic” and “can solve plastic waste” are very different thresholds.

    The bacterium almost completely degraded a PET film in about six weeks at 30C. But that film was extremely favorable material, thin and only about 1.9% crystalline.

    https://pmc.ncbi.nlm.nih.gov/articles/10546322/

    That’s important because a real PET bottle is much harder. PET chains in crystalline regions are packed tightly together, and the enzyme has trouble getting the polymer into its active site. Typical waste PET can have crystallinity above ~25%.

    https://doi.org/10.1007/s42452-025-07764-x

    Also, P. sakaiensis attacks PET, which is a polyester. It does not give us a general solution for:

    • polyethylene (PE) — shopping bags, films, many bottles
    • polypropylene (PP) — containers, caps, automotive plastics
    • polystyrene (PS)
    • PVC
    • PTFE

    PET happens to contain chemically convenient ester bonds:

    PET chain → ester bond → PETase can hydrolyze it
    

    Whereas polyethylene is basically:

    –C–C–C–C–C–C–
    

    There’s no corresponding easy hydrolysis reaction. That’s a much harder biochemical problem.

    So if you dumped P. sakaiensis into a landfill, it wouldn’t start consuming “the plastic.” It would encounter a giant mixed pile, only some of which is PET, and much of that PET would be physically difficult for it to attack.

    Maybe we can engineer something inspired by P. sakaiensis. I don’t think it overcomes the bigger hurdles by itself, though.



  • Wood is a biological material made from molecules that have been sitting in Earth’s biosphere for hundreds of millions of years:

    Wood
    → cellulose
    → hemicellulose
    → lignin
    → sugars/aromatic compounds
    → microbial metabolism

    Those molecules contain lots of chemically accessible bonds, especially C–O bonds. Plants built them using biological chemistry, so other biological chemistry can, in principle, take them apart.

    An enzyme isn’t a tiny animal chewing through plastic. It has to contact a polymer chain, bind it in an active site, chemically cleave a bond, release the products, and repeat.

    A plastic can thwart that by being:
    hydrophobic + highly crystalline + insoluble + chemically repetitive + physically inaccessible.

    There’s no evolutionary law saying organisms must eventually become capable of rapidly consuming any energetically favorable substance.

    Evolution has to find a chemically feasible pathway. And even if it does, decomposition might be:

    plastic bottle → 150 years
    

    rather than

    plastic bottle → three weeks.
    

    And amusingly, we could simply change the plastic. If PET suddenly became unsuitable for decades-long applications because PET-eating microbes became ubiquitous, we’d manufacture polymers resistant to those enzymes, add protective layers, alter crystallinity, or use different polymers.

    All and all, I’m doubtful microbes will come to our rescue. Unless we engineer them for the task, that is.